Technological advancements are rapidly transforming the labor market and have raised concerns about the Higher Education Institutions to fulfill their mission in the future. Meanwhile, students hope to learn relevant skills for current and future labor market needs. Action must be taken to prevent higher education from losing relevance, keeping it aligned with the changing labor market demands. To achieve this goal, we expand the concept of employability of undergraduate courses towards a future-oriented perspective. Based on this analysis, we propose the Future-oriented Higher Education Course Employability (Fo-HECE) concept. Thus, we identified a set of indicators regarding impacts on future employability. We employed Multi-criteria Decision-Making methods involving the collection of expert opinions, aiming to measure the influence of each indicator on the courses’ future employability. Results based on the Rank Sum method show that among the 14 factors analyzed, the five most important factors, in order, were Labor Market Adherence, Average Salary, Average Hiring Salary, Number of Students vs. Number of Jobs, and Probability of Automation. Our findings highlight the importance of aligning undergraduate courses with current and future labor market demands, as the top-5 most influential factors are related to the labor market context. This study narrows the gap between academia and industry to help students thrive in the evolving world of work while contributing to discussions and efforts to ensure the relevance and effectiveness of higher education in preparing students for the future labor market.